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我院生物治疗国家重点实验室逯光文团队与中检院李玉华团队共同在Science Advances发表论文,揭示I型牛疱疹病毒gD蛋白识别受体nectin-1能力较弱的结构基础 2020.05.18

JINRI,WOYUANSHENGWUZHILIAOGUOJIAZHONGDIANSHIYANSHIHEJIZHENKELUGUANGWENJIAOSHOUTUANDUIYUZHONGGUOSHIPINYAOPINJIANDINGYANJIUYUANLIYUHUAJIAOSHOUTUANDUIGONGTONGZAIGUOJIZHUMINGXUESHUQIKAN《Science Advances》(YINGXIANGYINZI:12.804)FABIAOLETIWEI“Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor”DELUNWEN,JIESHILEIXINGNIUPAOZHENBINGDU gDDANBAISHIBIESHOUTInectin-1NENGLIJIAORUODEJIEGOUJICHU。

IXINGNIUPAOZHENBINGDU(BHV-1)ZUICHUZUOWEIJIQUANSHIJIEZAOCHENGZHONGDAJINGJIWEIXIEDENONGYEBINGYUANTIBEIDAJIASUOSHUZHI。JINNIANLAI,BHV-1ZUOWEIRONGLIUBINGDUDEQIANZAIYINGYONGJIAZHIZHUJIANYINQIRENMENDEGUANZHU。BHV-1KEYIGANRANHESHASIDUOZHONGZUZHILAIYUANDEZHONGLIUXIBAO,YOUWANGCHENGWEIYIZHONGGUANGPUDERONGLIUBINGDUZAITI。BHV-1KEYITONGGUOBINGDUBIAOMIANNANGMOTANGDANBAIgDSHIBIEHEJIEHEXIBAOBIAOMIANSHOUTInectin-1ERQISHIBINGDUGANRAN。YOUYANJIUBIAOMING,YUTONGBINGDUYAKEDEQITAαPAOZHENBINGDU(RUHSV-1、HSV-2HEPRVDENG)DEgDDANBAIXIANGBI,BHV-1 gDJIEHEnectin-1DENENGLIJIAORUO。RANER,MUQIANHAIMEIYOUGUANYUBHV-1 gDHEnectin-1XIANGHUZUOYONGJIZHIJIYUSHOUTIJIANQINHELIJIAORUODEJIZHIYANJIU。

ZAICIXIANGGONGZUOZHONG,YANJIURENYUANGONGQUDELELIANGFANGMIANDETUPO:YISHI,SHOUCIJIEXILEBHV-1 gDDANBAIHEgD/nectin-1DANBAIFUHEWUDEGAOFENBIANLVJINGTIJIEGOU,JIESHILEBHV-1 gDSHIBIEnectin-1SHOUTIDEFENZIJIZHI;ERSHI,POYILEYINGXIANGBHV-1 gDJIEHEnectin-1SHOUTINENGLIJIAORUODEJIEGOUJICHU,ZHAODAOLEgDDANBAISHANGZUAISHOUTIJIEHEDEGUANJIANANJISUAN,BINGCHENGGONGZHIBEILEYUSHOUTIQINHELIXIANZHUTIGAODEgDTUBIANTIDANBAI。GAIYANJIUCHENGGUOYUJIJIANGWEIJIYUBHV-1DERONGLIUBINGDUDEHELISHEJITIGONGLILUNYIJU。

WOYUANJIZHENKEJISHENGWUZHILIAOGUOJIAZHONGDIANSHIYANSHIWEIGAILUNWENDEDIYIWANCHENGDANWEI,SHENGWUZHILIAOGUOZHONGBOSHIYANJIUSHENGYUEDANWEILUNWENDIYIZUOZHE。LUGUANGWENJIAOSHOUHELIYUHUAJIAOSHOUWEILUNWENGONGTONGTONGXUNZUOZHE。

GAIXIANGYANJIUDEDAOLEGUOJIAZIRANKEXUEJIJIN(81971925,31570157)、GUOJIAGUOJIKEJIHEZUOZHUANXIANG(2015DFA30690)、GUOJIAZHONGDIANYANFAJIHUA(2016YFC1200305)HESICHUANDAXUEYOUXIUQINGNIANJIJIN(2016SCU04B01)DEZIZHU。


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作者:沈国波 编辑:史杰蔚 周亮 来源:生物与治疗国家重点实验室/科研三支部
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